CAPP2 Study Suggests People With Lynch Syndrome Should Take Aspirin To Reduce Colorectal Cancer Risk

Those taking aspirin for at least 2 years had a meaningful reduction in colorectal cancer risk and the protective effect lasts for many years.

Study Background:
Lynch syndrome is associated with an increased risk of colorectal cancer and with a broader spectrum of cancers, especially endometrial cancer. In 2011, our group reported long-term cancer outcomes (mean follow-up 55·7 months [SD 31·4]) for participants with Lynch syndrome enrolled into a randomised trial of daily aspirin versus placebo. This report completes the planned 10-year follow-up to allow a longer-term assessment of the effect of taking regular aspirin in this high-risk population.

Learn More:
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30366-4/fulltext